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Insights | April 9, 2025
An exposure pathway refers to the process by which a harmful agent, such as a chemical or biological hazard, reaches a worker and is absorbed into the body. This can occur through different routes including inhalation, skin absorption, injection, or ingestion. Understanding these exposure pathways is essential in determining the potential for harm and the most effective way to control or mitigate exposure.
The key components of an exposure pathway include:
Source of Contaminant
The source of the contaminant is the origin of a hazardous substance or condition. Examples include machinery, material transfer/transport, chemical spills, or cleaning activities.
Mechanism of Transport
The mechanism of transport is how the contaminant is transported from the source to the receptor. For example, contaminants may travel through the air (aerosols, dust, fumes), water (chemical spills), or by surfaces (contact with contaminated equipment or materials).
Exposure Point
The exposure point is where a worker comes into contact with a hazard in their workplace or work process.
Route of Entry Into the Body
The route of entry is how a worker comes into contact with a hazard, either through the respiratory system (inhalation), skin (dermal absorption), beneath the skin (injection), or digestive system (ingestion).
Receptor
The receptor is the individual exposed to a hazard. The receptor’s health condition, protective equipment, and work practices can all influence the extent of exposure.
Exposure pathways can be classified into four different types depending on the nature of the contaminant and the way it enters the body. The primary pathways of concern when conducting an industrial hygiene assessment are:
Inhalation Pathway
The inhalation of airborne contaminants is one of the most common and dangerous exposure pathways, especially in manufacturing and industrial settings. Airborne contaminants such as dusts, fumes, vapors, gases, and aerosols can all be inhaled into the lungs where they can cause damage to the respiratory system or be directly absorbed into the body, potentially causing respiratory illnesses, neurological damage, or cancer. For example, asbestos fibers, silica dust, and welding fumes can be inhaled by workers if proper ventilation or respiratory protection is not in place.
Dermal (Skin) Absorption
Some harmful substances can be absorbed through the skin. This is particularly relevant for chemicals, oils, solvents, and certain biological agents that can penetrate the skin and enter the bloodstream. Examples where dermal exposure is a concern include workplaces where employees handle substances like pesticides, cleaning agents, or industrial lubricants.
Injection Pathway
While rare, injection of a hazardous substance can occur in certain industries. This can happen through accidents such as puncture wounds from contaminated needles, nails, or sharp equipment. Injection pathways are particularly relevant in healthcare or manufacturing environments dealing with sharp materials.
Ingestion Pathway
The ingestion pathway refers to the route of exposure where a substance enters the body through the mouth and digestive system, such as by consuming contaminated food, water, or soil. This type of pathway is often associated with poor hygiene practices or the contamination of workplace surfaces, equipment, or food storage areas. Although less common than inhalation or dermal exposure, ingestion can occur in environments where workers eat or drink in contaminated areas or fail to wash their hands before meals.
An exposure pathway can occur under various circumstances including accidental spills, leaks, and releases of a toxic agent, or through planned releases that are part of routine, standard operational procedures of a facility. Once released, there could also be ways for the hazard to travel beyond the source, potentially creating a risk or exposure for a greater number of workers or to the community. Different ways by which a hazard can travel include air, water, soil, or surface contamination. Understanding the possible exposure pathways and their potential for travel is essential in determining the most appropriate exposure monitoring strategy for an industrial hygiene assessment.
Understanding exposure pathways is a cornerstone of industrial hygiene for several reasons:
Risk Assessment and Control Measures
By understanding the exposure pathways, industrial hygienists can assess the level of risk to workers. This information is crucial for developing targeted control measures that are appropriate for the specific type of exposure. For instance, inhalation risks may require improved ventilation systems, while dermal exposure risks may necessitate the use of personal protective equipment.
Prioritizing Hazards
Not all exposure pathways carry the same level of risk. Understanding the different pathways helps prioritize which hazards should be addressed first. For example, airborne contaminants might pose an immediate risk to respiratory health, and thus controlling the inhalation pathway may be more urgent than addressing dermal exposure to chemicals.
Preventive Strategies
Understanding how a contaminant enters the body allows industrial hygienists to conduct effective exposure monitoring campaigns and design preventive strategies that block the pathways. For example, if a hazardous substance is airborne, then installing local exhaust ventilation or providing respirators can reduce the risk of inhalation. Similarly, if a substance can be absorbed through the skin, then personal protective equipment may be recommended.
Compliance with Regulations
Exposure pathways are closely tied to workplace regulations and standards, such as those established by OSHA (Occupational Safety and Health Administration) or NIOSH (National Institute for Occupational Safety and Health). By understanding the pathways, employers can ensure compliance with legal requirements and avoid health risks to workers.
Once the exposure pathway is understood, control strategies can be implemented. These strategies are modeled after the industrial hygiene hierarchy of controls which prioritizes strategies for controlling hazards from the most to least effective, as follows: elimination, substitution, engineering controls, administrative controls, and personal protective equipment (PPE).
Elimination
Elimination involves the complete removal of the hazard from the workplace. An example is removing a chemical from a process altogether. This is the most effective control strategy as it completely removes the risk, eliminating any potential for worker harm.
Substitution
Substitution is based on replacing a hazardous substance or process with a less hazardous alternative. Examples include using a less toxic agent to reduce exposure to harmful chemicals or substituting a manual task with an automated one. While this strategy does not eliminate a hazard altogether, and a new material or process may still have some inherent risks, an effective use of substitution can ultimately lower the risk of exposure.
Engineering Controls
Implementing engineering controls can isolate workers from hazardous exposures through physical means. Examples include ventilation systems that remove harmful airborne contaminants, enclosures that separate workers from a hazard, or other engineered strategies that design or redesign a workplace or work process in a way that reduces exposure. Ideally, engineering controls are designed to function automatically, thereby reducing any reliance on human behavior and making this strategy more effective than administrative controls or personal protective equipment.
Administrative Controls
Using administrative controls involves changing workplace policies, practices, or procedures to minimize worker exposure to harmful agents. Examples include limiting the amount of time that workers are exposed to a hazard, scheduling job tasks when exposure is lower, or providing employee training on how to work with or around harmful agents in a way that will reduce the likelihood of exposure. This strategy can help reduce worker exposure but is reliant on employee awareness and compliance, making it less dependable than the higher-level control strategies.
Personal Protective Equipment (PPE)
The use of personal protective equipment, or PPE, to protect workers from exposure to hazards may be necessary when other controls are insufficient or not feasible. Examples of PPE include respirators to protect against airborne contaminants, earplugs to protect against noise, or gloves and full-body disposable protective suits to guard against contact with chemicals. PPE is considered the least effective control strategy as it relies on proper maintenance and use and does not address the source of a harmful exposure, and should be considered the last option for protecting workers.
The goal of industrial hygiene is always to implement controls as high up in the hierarchy as possible to minimize the need for PPE and reduce the risk to workers.
Exposure pathways are a fundamental concept in industrial hygiene that directly influences worker health and safety. By identifying the source of a contaminant, mechanism of transport, exposure point, and route of exposure, industrial hygienists can perform exposure monitoring to assess the risks associated with various hazards and subsequently develop the most appropriate control measures. Understanding and addressing these pathways is essential to protecting workers’ health, complying with safety regulations, and ultimately creating an environment that is safer for both workers and the community.